Simultaneous Determination of Ezetimibe and Simvastatin in Pharmaceutical Preparations by MEKC
نویسندگان
چکیده
منابع مشابه
Simultaneous determination of ezetimibe and simvastatin in pharmaceutical preparations by MEKC.
A micellar electrokinetic capillary chromatography method was developed and validated for the simultaneous determination of ezetimibe and simvastatin in pharmaceutical preparations. The influence of buffer concentration, buffer pH, sodium dodecyl sulphate (SDS) concentration, organic modifier, capillary temperature, applied voltage, and injection time was investigated, and the method validation...
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Two spectrophotometric methods are described for the simultaneous determination of ezetimibe (EZE) and simvastatin (SIM) in pharmaceutical preparations. The obtained data was evaluated by using two different chemometric techniques, Principal Component Regression (PCR) and Partial Least-Squares (PLS-1). In these techniques, the concentration data matrix was prepared by using the mixtures contain...
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A simple, precise and rapid RP-HPLC method was developed for the simultaneous determination of simvastatin and ezetimibe in combined pharmaceutical dosage forms. The method was carried out on a Shim-pack, RP-C18 column using a mixture of acetonitrile: methanol: buffer (triethylamine pH-3) in the ratio 15:45:40 and detection was done at 240 nm using external standard method as quantitation. The ...
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ژورنال
عنوان ژورنال: Journal of Chromatographic Science
سال: 2010
ISSN: 0021-9665,1945-239X
DOI: 10.1093/chromsci/48.2.95